Anaesthesia-related mortality within 24 h following 9,391,669 anaesthetics in 10 cities in Hubei Province, China: a serial cross-sectional study

BackgroundThe mortality risk related to anaesthesia in China remains poorly characterized. The objective of this study was evaluate the anaesthesia-related terms its incidence, changes, causes and preventability Hubei, China, between 2017 2021 using a series annual surveys.MethodsWe prospectively collected information on patient, surgical, anaesthesia, hospital characteristics for 9,391,669 procedures performed 10 cities within Hubei Province, China. Anaesthesia-related death defined as that deemed be entirely or partially attributable occurring 24 h following administration. All fatalities were scrutinized consecutively determine their root preventability. incidence patterns deaths analysed from 2021. A mixed-effects model with Poisson link function fitted city-level changes risk-adjusted deaths.Findings600 cases anaesthetic occurred 2021, yielding an 6.4 per 100,000 [95% confidence interval (95% CI): 5.9, 6.9], most preventable (71.3%). There significant decrease incidences across all patients, those American Society Anaesthesiologists physical status (ASAPS) ≥III, who had general percentage reduction 57.6%, 59.1%, 55.9%, respectively. indicated downward trends 2018, 2019, 2020, For instance, −2.5 CI: −1.4, −4.7).InterpretationIn large, comprehensive database conducted Central 100,000. Notably, decreased However, further in-depth analysis is needed understand extent which these represent change patient safety.FundingInnovation optimization perioperative respiratory system management strategy (Hubei Technological Innovation Special Fund, 2019ACA167). surveys. We deaths. 600 −4.7). In safety.